Some people who use cocaine take it regularly; others binge, sometimes for days, and then stop use for a while. How drug seeking increases during abstinence (called incubation of craving) is of great interest to scientists.
Studying rats exposed to cocaine, researchers at NIDA’s Intramural Research Program (IRP) wanted to determine if the incubation of craving would be different in male and female rats and if the effect is stronger after binge cocaine intake, compared to continuous use. Results have recently been published in the journal Biological Psychiatry.
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