Key role of the dopamine D4 receptor in the modulation of corticostriatal glutamatergic neurotransmission. Polymorphic variants of the dopamine D4 receptor gene (DRD4) have been repeatedly associated with numerous neuropsychiatric disorders. Yet, the functional role of the D4 receptor and the functional differences of the products of DRD4 polymorphic variants remained enigmatic. Immunohistochemical and optogenetic-microdialysis experiments were performed in knock-in mice expressing a D4 receptor with the long intracellular domain of a human DRD4 polymorphic variant associated with attention deficit hyperactivity disorder (ADHD)…
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Sci Adv. 2017 Jan 11;3(1):e1601631. doi: 10.1126/sciadv.1601631. eCollection 2017.
Bonaventura J, Quiroz C, Cai NS, Rubinstein M, Tanda G, Ferré S.
